Hydrochloric Acid → HCID 68535367, Verbindung

HRID 1910389Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1910389
[S:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH2:7][CH2:8][N:9](C(OC(C)(C)C)=O)[CH2:10][CH:11]=2)=[CH:2]1.[ClH:19]>CCOC(C)=O.O>[ClH:19].[S:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH2:7][CH2:8][NH:9][CH2:10][CH:11]=2)=[CH:2]1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 58913281HCID 58913281, Verbindung

Produkt 1

HCID 68535367HCID 68535367, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8857Ethyl AcetateLösungsmittel2×

Versuchsvorschrift

To a solution of tert-butyl 4-(3-thienyl)-3,6-dihydropyridine-1(2H)-carboxylate (170 mg) in EtOAc (1.7 ml) and water (0.085 ml) was added 4 N hydrogen chloride in EtOAc (1.7 ml) and the mixture was stirred at room temperature for 1 hour. Solvent was removed in vacuo to give 4-(3-thienyl)-1,2,3,6-tetrahydropyridine hydrochloride (120 mg) as a dark gray powder. The obtained crude product was used in next reaction without further purification.

Aufarbeitung

  1. customSolvent was removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-68cb2a33a49e434f84dc63f1ea3429ec
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08603975B2

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