Formic Acid → HCID 20116475, Verbindung

HRID 1910768Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1910768
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH2:11][C:12]([OH:14])=[O:13])=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH:15](O)=O>C=O>[CH3:15][N:10]([CH2:11][C:12]([OH:14])=[O:13])[C:7]1[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=1

Komponenten

4

Edukt 2

HCID 284Formic AcidHCID 12095Glycine, N-(4-nitrophenyl)-

Produkt 1

HCID 20116475HCID 20116475, VerbindungAusbeute 86 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 712FormaldehydeLösungsmittel

Versuchsvorschrift

A solution of (4-nitro-phenylamino)-acetic acid (1.3 g, 6.6 mmol) in formic acid (5 mL) and formaldehyde (5 mL) was heated at reflux overnight. The mixture was concentrated in vacuo and 1N hydrochloric acid added to the residue giving a pH ˜3. The mixture was extracted with ethyl acetate then the organic phase was washed with water and brine. Concentration in vacuo afforded [methyl-(4-nitro-phenyl)-amino]-acetic acid (1.2 g, 86%) as a yellow solid.

Aufarbeitung

  1. temperatureat reflux overnight
  2. concentrationThe mixture was concentrated in vacuo and 1N hydrochloric acid
  3. additionadded to the residue
  4. customgiving a pH ˜3
  5. extractionThe mixture was extracted with ethyl acetate
  6. washthe organic phase was washed with water and brine
  7. concentrationConcentration in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-62628ced33c44bd5aa2bf325b5abea16
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08604029B2

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