Hydrochloric Acid → 2-(Piperazin-1-yl)propan-1-ol

HRID 1911412Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1911412
[OH:1][CH2:2][CH:3]([N:5]1[CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6]1)[CH3:4].Cl.O1CCOCC1>C(OCC)(=O)C.CO.CCOCC>[N:5]1([CH:3]([CH3:4])[CH2:2][OH:1])[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1

Komponenten

7

Edukt 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 50987509Tert-butyl 4-(1-hydroxypropan-2-yl)piperazine-1-carboxylate

Produkt 1

HCID 706292-(Piperazin-1-yl)propan-1-olAusbeute 113,8 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 887MethanolLösungsmittelHCID 3283Diethyl EtherLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A suspension of tert-butyl 4-(1-hydroxypropan-2-yl)piperazine-1-carboxylate (0.782 g, 3.2 mmol) in a mixture of ethyl acetate (10 ml) and methanol (10.00 mL), was treated drop-wise with 4.0M HCl in dioxane (12.00 ml, 48.00 mmol) at room temperature. The reaction mixture was stirred for 18 h. The reaction mixture was diluted with ether and the white solid filtered off, washed with ether and air dried to give 2-(piperazin-1-yl)propan-1-ol (0.525 g, 76%), as its dihydrochloride salt.

Aufarbeitung

  1. filtrationthe white solid filtered off
  2. washwashed with ether and air
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-9bcf92eded784b58a2c9bca317f02da0
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08604022B2

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