Adenine → 9-(4-nitro-phenyl)-9H-purin-6-ylamine

HRID 1912859

Reaktionsgleichung

Reaktionsgleichung von HRID 1912859
[N:1]1[C:9]([NH2:10])=[C:8]2[C:4]([N:5]=[CH:6][NH:7]2)=[N:3][CH:2]=1.CC(C)([O-])C.[K+].F[C:18]1[CH:23]=[CH:22][C:21]([N+:24]([O-:26])=[O:25])=[CH:20][CH:19]=1>CS(C)=O.O>[N+:24]([C:21]1[CH:22]=[CH:23][C:18]([N:5]2[CH:6]=[N:7][C:8]3[C:4]2=[N:3][CH:2]=[N:1][C:9]=3[NH2:10])=[CH:19][CH:20]=1)([O-:26])=[O:25]

Komponenten

6

Edukt 3

HCID 190AdenineHCID 9590p-FluoronitrobenzeneHCID 23665647Potassium tert-butoxide

Produkt 1

HCID 3090939-(4-nitro-phenyl)-9H-purin-6-ylamineAusbeute 93,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 679Dimethyl SulfoxideLösungsmittelHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

In 100 ml of dimethyl sulfoxide, 4.05 g (30.0 mmol) of adenine was dissolved, and 3.5 g (31.0 mmol) of potassium tert-butoxide and 5.0 g (35.0 mmol) of 4-fluoronitrobenzene were added thereto, and the mixture solution was stirred at 80° C. for three hours. The solution was diluted with 200 mL of water and the precipitate formed was collected by filtration, washed with 100 mL of water and 30 mL of methanol in the order named and vacuum dried to obtain 7.2 g (84%) of a target product as a yellow solid.

Aufarbeitung

  1. customthe precipitate formed
  2. filtrationwas collected by filtration
  3. washwashed with 100 mL of water and 30 mL of methanol in the order
  4. customvacuum dried

Quellen und Nachweise

ORD-Eintrag
ord-fc675b0af2b8458d801a87703d3d2378
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08609656B2

Verknüpfte Notizen

Wird geladen…