Hydrochloric Acid → Ethyl 1-methyl-4-oxocyclohexanecarboxylate

HRID 1913235

Reaktionsgleichung

Reaktionsgleichung von HRID 1913235
[CH3:1][C:2]1([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:11][CH2:10][C:5]2(OCC[O:6]2)[CH2:4][CH2:3]1.CCO.O.Cl>O1CCOCC1>[CH3:1][C:2]1([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:3][CH2:4][C:5](=[O:6])[CH2:10][CH2:11]1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 962WaterHCID 19004805Ethyl 8-methyl-1,4-dioxaspiro[4.5]decane-8-carboxylate

Produkt 1

HCID 21911973Ethyl 1-methyl-4-oxocyclohexanecarboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

In a 50 mL round-bottom flask was mixed with ethyl 8-methyl-1,4-dioxaspiro[4.5]decane-8-carboxylate (Int-6a, 1.99 g, 8.72 mmol), EtOH (10 mL), H2O (5 mL), and 4N HCl in 1,4-dioxane (5 mL). The resulting solution was stirred at room temperature for 64 hours. At this time, the solvent was removed in vacuo and the residue was taken up in DCM. The suspension was washed with saturated NaHCO3(aq) and the organic layer was dried over Na2SO4. The resulting product was taken on without further purification. Yield=1.00 g.

Aufarbeitung

  1. customAt this time, the solvent was removed in vacuo
  2. washThe suspension was washed with saturated NaHCO3(aq)
  3. dry with materialthe organic layer was dried over Na2SO4
  4. customThe resulting product was taken on without further purification

Quellen und Nachweise

ORD-Eintrag
ord-d027fab779754691829fdfd85cf0c6a8
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08609675B2

Verknüpfte Notizen

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