Water → Propan-2-yl 4-amino-3,6-dichloro-5-fluoropicolinate

Reaktionsgleichung

[NH2:1][C:2]1[C:7]([F:8])=[C:6]([Cl:9])[N:5]=[C:4]([C:10]([O:12][CH:13]([CH3:15])[CH3:14])=[O:11])[CH:3]=1.O.CCOC(C)=O.CCCCCC.C(Cl)[Cl:30]>>[NH2:1][C:2]1[C:7]([F:8])=[C:6]([Cl:9])[N:5]=[C:4]([C:10]([O:12][CH:13]([CH3:15])[CH3:14])=[O:11])[C:3]=1[Cl:30]

Komponenten

Edukt 4

HCID 962Water

HCID 6344Dichloromethane

HCID 21226206Ethyl acetate hexane

HCID 71551782Isopropyl 4-amino-6-chloro-5-fluoropicolinate

Produkt 1

HCID 71551839Propan-2-yl 4-amino-3,6-dichloro-5-fluoropicolinateAusbeute 28 %

Versuchsvorschrift

Propan-2-yl 4-amino-6-chloro-5-fluoropicolinate (1.191 g, 5.12 mmol) was almost completely dissolved in CH2Cl2 (40 mL). Water (40 mL) was added. Chlorine was bubbled through the solution for 5 min. After 30 min, an aliquot of the reaction mixture was analyzed by GC, showing desired product and only 1.7% starting material. The aqueous layer was separated and extracted with CH2Cl2 (50 mL). The combined organic extracts were washed with satd aq NaHCO3 solution and then brine. The extracts were dried (MgSO4) and concentrated under reduced pressure to yield an orange oil. Flash chromatography (120 g silica column; 0-50% EtOAc-hexane gradient) afforded a bright yellow crystalline solid (394 mg, 28%): 1H NMR (400 MHz, CDCl3) δ 5.29 (septet, J=6.3 Hz, 1H, CHMe2), 5.19 (br s, 2H, NH2), 1.40 (d, J=6.3 Hz, 6H, CHMe2); 13C{1H} NMR (101 MHz, CDCl3) δ 163.2 (CO2R), 143.3 (d, JF-C=5 Hz, C2), 142.8 (d, JF-C=270 Hz, C5), 141.0 (d, JF-C=26 Hz, C4), 135.3 (d, JF-C=17 Hz, C6), 114.9 (s, C3), 70.6 (CHMe2), 21.6 (s, Me); 19F NMR (376 MHz, CDCl3) δ −136.5.