1-(4-Methoxy-3-nitrophenyl)-4-methylpiperazine → HCID 24994141, Verbindung
Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][N:12]([CH3:15])[CH2:11][CH2:10]2)=[CH:5][C:4]=1[N+:16]([O-])=O>CO.[Pd]>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:10][CH2:11][N:12]([CH3:15])[CH2:13][CH2:14]2)=[CH:5][C:4]=1[NH2:16]Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A solution of 1-(4-methoxy-3-nitro-phenyl)-4-methyl-piperazine (1.0 g, 4.0 mmol) in MeOH (100 mL) in the presence of Pd/C 10% (150 mg) was hydrogenated at 35 psi for 2 h. The mixture was filtered over a pad of celite and the solution was concentrated to afford 0.8 g (90% yield) of the title compound.
Aufarbeitung
- filtrationThe mixture was filtered over a pad of celite
- concentrationthe solution was concentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-da2faf56a50642e2a67cda9ee67d967e
- Quelldatensatz
- uspto-grants-2013_12
- Patentnummer
- US08614220B2
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