Sodium Hydroxide → HCID 67112454, Verbindung

HRID 1914808Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1914808
[NH2:1][C@H:2]1[CH2:6][CH2:5][C@@H:4]([C:7]([OH:9])=[O:8])[CH2:3]1.[OH-].[Na+].[C:12](Cl)(=[O:15])[CH2:13][CH3:14]>C1COCC1>[C:12]([NH:1][C@H:2]1[CH2:6][CH2:5][C@@H:4]([C:7]([OH:9])=[O:8])[CH2:3]1)(=[O:15])[CH2:13][CH3:14]

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 62324Propionyl chlorideHCID 1502035Cyclopentanecarboxylic acid, 3-amino-, (1R,3S)-rel- (9CI)

Produkt 1

HCID 67112454HCID 67112454, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

100.0 mg (0.77 mmol) (1R,3S)-3-Aminocyclopentane carboxylic acid is stirred in 2.0 mL THF and 0.77 mL (1.55 mmol) sodium hydroxide solution (2 mol/l). 74.0 μL (0.85 mmol) Propionyl chloride is added drop wise and the mixture is stirred at RT over night. The solvent is evaporated. The mixture is stirred at RT over night. The product is purified by RP-HPLC (water+5-95% acetonitrile (with addition of 0.1% TFA)) and lyophilized.

Aufarbeitung

  1. customThe solvent is evaporated
  2. stirringThe mixture is stirred at RT over night
  3. customThe product is purified by RP-HPLC (water+5-95% acetonitrile (with addition of 0.1% TFA))

Quellen und Nachweise

ORD-Eintrag
ord-2cd22e7d56e74f918aad4ab623987221
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08614238B2

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