Phosphorus pentachloride → (1-Ethyl-7-methoxy-2,2-dimethyl-1,2-dihydroquinol-4-yl)-methanesulfonic acid chloride

HRID 1914994Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1914994
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([CH2:13][S:14]([Cl:17])(=[O:16])=[O:15])=[CH:5][C:4]1([CH3:19])[CH3:18])[CH3:2].C(N1C2C(=CC=[C:29]([O:32]C)C=2)C(CS(O)(=O)=O)=CC1(C)C)C.P(Cl)(Cl)(Cl)(Cl)Cl>C1C=CC=CC=1>[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:32][CH3:29])[CH:11]=2)[C:6]([CH2:13][S:14]([Cl:17])(=[O:16])=[O:15])=[CH:5][C:4]1([CH3:18])[CH3:19])[CH3:2]

Komponenten

5

Edukt 3

HCID 24819Phosphorus pentachlorideHCID 12138182(1-Ethyl-2,2-dimethyl-1,2-dihydroquinol-4-yl)-methanesulfonic acid chlorideHCID 12138189(1-Ethyl-7-methoxy-2,2-dimethyl-1,2-dihydroquinol-4-yl)-methanesulfonic acid

Produkt 1

HCID 12138190(1-Ethyl-7-methoxy-2,2-dimethyl-1,2-dihydroquinol-4-yl)-methanesulfonic acid chlorideAusbeute 73 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

(1-Ethyl-7-methoxy-2,2-dimethyl-1,2-dihydroquinol-4-yl)-methanesulfonic acid chloride (16) is prepared similarly to compound (9) from compound (15) and phosphorus pentachloride in dry benzene. The acid chloride that is obtained is immediately used for further reaction.

Quellen und Nachweise

ORD-Eintrag
ord-37bd0ec4612246d6abbed01f9b4f61f0
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08614317B2

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