Tert-butyl 4-{2-[(4-bromophenyl)amino]-1-methylbenzimidazol-5-yloxy}pyridine-2-carboxylate → HCID 22040646, Verbindung

HRID 1915626

Reaktionsgleichung

Reaktionsgleichung von HRID 1915626
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:13]([CH3:14])[C:12]3[CH:15]=[CH:16][C:17]([O:19][C:20]4[CH:25]=[CH:24][N:23]=[C:22]([C:26]([O:28]C(C)(C)C)=[O:27])[CH:21]=4)=[CH:18][C:11]=3[N:10]=2)=[CH:4][CH:3]=1>FC(F)(F)C(O)=O.O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:13]([CH3:14])[C:12]3[CH:15]=[CH:16][C:17]([O:19][C:20]4[CH:25]=[CH:24][N:23]=[C:22]([C:26]([OH:28])=[O:27])[CH:21]=4)=[CH:18][C:11]=3[N:10]=2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 1

HCID 22041284Tert-butyl 4-{2-[(4-bromophenyl)amino]-1-methylbenzimidazol-5-yloxy}pyridine-2-carboxylate

Produkt 1

HCID 22040646HCID 22040646, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterKatalysatorHCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

A solution of the product of step 7 in trifluoroacetic acid was treated with two drops of water at room temperature for 3-4 hours or until the reaction was determined to be complete by HPLC. The reaction was evaporated under reduced pressure to afford the product as a red-orange oil in quantitative yield. MS: MH+=439.

Aufarbeitung

  1. customThe reaction was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-3ab6b78687df44d2943a575f7769649f
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08614330B2

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