Lithium hydroxide, monohydrate → (s)-2-[4-(2-Fluoro-3-pyrrolidin-1-yl-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid lithium salt
Reaktionsgleichung
C([O:3][C:4](=[O:29])[C@@H:5]([N:10]1[CH2:14][C:13]([O:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([N:22]3[CH2:26][CH2:25][CH2:24][CH2:23]3)[C:17]=2[F:27])=[CH:12][C:11]1=[O:28])[CH2:6][CH:7]([CH3:9])[CH3:8])C.O.[OH-].[Li+:32]>O1CCCC1>[Li+:32].[F:27][C:17]1[C:18]([N:22]2[CH2:23][CH2:24][CH2:25][CH2:26]2)=[CH:19][CH:20]=[CH:21][C:16]=1[O:15][C:13]1[CH2:14][N:10]([C@@H:5]([CH2:6][CH:7]([CH3:9])[CH3:8])[C:4]([O-:29])=[O:3])[C:11](=[O:28])[CH:12]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 25 °C
Versuchsvorschrift
To a solution containing (S)-2-[4-(2-fluoro-3-pyrrolidin-1-yl-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid ethyl ester (0.120 g, 0.29 mmol) in tetrahydrofuran (4 mL) was treated with an aqueous solution of lithium hydroxide monohydrate (0.5N, 1.2 mL, 0.6 mmol). The mixture was stirred at 25° C. for 2 h, and the solvents evaporated. The residue was rinsed with diethyl ether which afforded (S)-2-[4-(2-fluoro-3-pyrrolidin-1-yl-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid lithium salt (0.140 g, 100%) as a yellow solid.
Aufarbeitung
- customthe solvents evaporated
- washThe residue was rinsed with diethyl ether which
Quellen und Nachweise
- ORD-Eintrag
- ord-1975987fe34a4f76bffb36371302f57d
- Quelldatensatz
- uspto-grants-2010_06
- Patentnummer
- US07741327B2
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