Tetrabutylammonium Fluoride → 3-(4-Chloro-phenyl)-6-ethynyl-pyridazine

HRID 1916671Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1916671
CCCC[N+](CCCC)(CCCC)CCCC.[F-].[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]2[N:27]=[N:28][C:29]([C:32]#[C:33][Si](C)(C)C)=[CH:30][CH:31]=2)=[CH:22][CH:21]=1>C(Cl)Cl>[Cl:19][C:20]1[CH:21]=[CH:22][C:23]([C:26]2[N:27]=[N:28][C:29]([C:32]#[CH:33])=[CH:30][CH:31]=2)=[CH:24][CH:25]=1

Komponenten

4

Edukt 2

HCID 2724141Tetrabutylammonium FluorideHCID 673622923-(4-Chloro-phenyl)-6-trimethylsilanylethynyl-pyridazine

Produkt 1

HCID 859696873-(4-Chloro-phenyl)-6-ethynyl-pyridazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

1.10 g (3.49 mmol) TBAF are added at 0° C. to a solution of 1.00 g (3.49 mmol) 3-(4-chloro-phenyl)-6-trimethylsilanylethynyl-pyridazine in 10 mL DCM. The ice bath is removed and the reaction solution is stirred for 30 min. Water is added and the aqueous phase is extracted with EtOAc. The organic phase is dried over MgSO4 and the solvent is eliminated i.vac. The product is reacted without any further purification.

Aufarbeitung

  1. customThe ice bath is removed
  2. additionWater is added
  3. extractionthe aqueous phase is extracted with EtOAc
  4. dry with materialThe organic phase is dried over MgSO4
  5. customThe product is reacted without any further purification

Quellen und Nachweise

ORD-Eintrag
ord-ff938ebd871b4c57badc031aea30ff81
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08618132B2

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