Potassium Carbonate → 5-Bromo-2-pyrrolidin-1-ylmethyl-benzoxazole

HRID 1916761Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1916761
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH2:10]Cl)=[N:7][C:6]=2[CH:12]=1.C([O-])([O-])=O.[K+].[K+].[NH:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1>CN(C=O)C.O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH2:10][N:19]3[CH2:23][CH2:22][CH2:21][CH2:20]3)=[N:7][C:6]=2[CH:12]=1

Komponenten

6

Edukt 3

HCID 11430Potassium CarbonateHCID 31268PyrrolidineHCID 142042085-Bromo-2-(chloromethyl)-1,3-benzoxazole

Produkt 1

HCID 673655735-Bromo-2-pyrrolidin-1-ylmethyl-benzoxazole

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A solution of 2 g (8.11 mmol) 5-bromo-2-chloromethyl-benzoxazole in 30 mL DMF is combined with 2.24 g (16.22 mmol) K2CO3 and 0.9 mL (10.78 mmol) pyrrolidine and stirred for 24 hours at RT. The reaction mixture is diluted with water and extracted with EtOAc. The organic phase is dried over Na2SO4, the desiccant is filtered off and the filtrate is evaporated down.

Aufarbeitung

  1. extractionextracted with EtOAc
  2. dry with materialThe organic phase is dried over Na2SO4
  3. filtrationthe desiccant is filtered off
  4. customthe filtrate is evaporated down

Quellen und Nachweise

ORD-Eintrag
ord-60132da22cba45ec88c52177cc03b648
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08618132B2

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