4-Chlorobenzoyl chloride → 4-Chloro-N-[2-methyl-4-(2-(S)-methyl-[1,3'(S)]bipyrrolidinyl-1'-yl)-phenyl]-benzamide

HRID 1916918Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1916918
[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][C@H:10]([N:13]3[CH2:17][CH2:16][CH2:15][C@@H:14]3[CH3:18])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH2:19].[Cl:20][C:21]1[CH:29]=[CH:28][C:24]([C:25](Cl)=[O:26])=[CH:23][CH:22]=1>>[Cl:20][C:21]1[CH:29]=[CH:28][C:24]([C:25]([NH:19][C:3]2[CH:4]=[CH:5][C:6]([N:8]3[CH2:12][CH2:11][C@H:10]([N:13]4[CH2:17][CH2:16][CH2:15][C@@H:14]4[CH3:18])[CH2:9]3)=[CH:7][C:2]=2[CH3:1])=[O:26])=[CH:23][CH:22]=1

Komponenten

3

Edukt 2

HCID 85014-Chlorobenzoyl chlorideHCID 594017642-methyl-4-(2-(S)-methyl-[1,3'(S)]bipyrrolidinyl-1'-yl)-phenylamine

Produkt 1

HCID 594018814-Chloro-N-[2-methyl-4-(2-(S)-methyl-[1,3'(S)]bipyrrolidinyl-1'-yl)-phenyl]-benzamide

Versuchsvorschrift

The title compound was prepared in a manner substantially the same as Example 1 by coupling 2-methyl-4-(2-(S)-methyl-[1,3′(S)]bipyrrolidinyl-1′-yl)-phenylamine with 4-chloro-benzoyl chloride. LCMS: RT=3.96 minutes, MS: 398 (M+H).

Quellen und Nachweise

ORD-Eintrag
ord-c7d84c691374407a920fb4daf42ca1fe
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08618159B2

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