Acetic Acid → HCID 58505643, Verbindung

HRID 1917603Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1917603
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[N:18]3[C:13]([CH:14]=[C:15]([O:19][CH2:20][C:21]4[CH:26]=[CH:25][CH:24]=[C:23]([O:27][CH3:28])[N:22]=4)[CH:16]=[CH:17]3)=[C:12]([C:29](=[O:34])[C:30]([CH3:33])([CH3:32])[CH3:31])[C:11]=2[CH2:35][C:36]([CH3:43])([CH3:42])[C:37]([O:39]CC)=[O:38])=[O:9])=[CH:4][CH:3]=1.CC(O)=O>C1COCC1.[OH-].[Na+]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([C:10]2[N:18]3[C:13]([CH:14]=[C:15]([O:19][CH2:20][C:21]4[CH:26]=[CH:25][CH:24]=[C:23]([O:27][CH3:28])[N:22]=4)[CH:16]=[CH:17]3)=[C:12]([C:29](=[O:34])[C:30]([CH3:32])([CH3:33])[CH3:31])[C:11]=2[CH2:35][C:36]([CH3:43])([CH3:42])[C:37]([OH:39])=[O:38])=[O:9])=[CH:6][CH:7]=1

Komponenten

5

Edukt 2

HCID 176Acetic AcidHCID 58505712HCID 58505712, Verbindung

Produkt 1

HCID 58505643HCID 58505643, VerbindungAusbeute 99,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8028TetrahydrofuranLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

A solution of ethyl 3-{3-[(4-chlorophenyl)carbonyl]-1-(2,2-dimethylpropanoyl)-7-[(6-methoxypyridin-2-yl)methoxy]indolizin-2-yl}-2,2-dimethylpropanoate (20 mg, 0.033 mmol) in THF (2.0 mL) and 10M aqueous NaOH (1.5 mL) is heated at 45° C. for 1.5 h. The mixture is then acidified with HOAc, concentrated in vacuo, and partitioned between EtOAc and water. The organics are collected, dried with MgSO4, filtered, and concentrated in vacuo to give the title compound (19 mg, quant).

Aufarbeitung

  1. concentrationconcentrated in vacuo
  2. custompartitioned between EtOAc and water
  3. customThe organics are collected
  4. dry with materialdried with MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-19cf73d45fd94019a2344bf8dca9d781
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08618300B2

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