Methane → 4-(2-Hydroxyethyl)piperidin-4-ol
Reaktionsgleichung
C([N:8]1[CH2:13][CH2:12][C:11]([CH2:15][CH2:16][OH:17])([OH:14])[CH2:10][CH2:9]1)C1C=CC=CC=1.C>CO.[OH-].[Pd+2].[OH-]>[OH:17][CH2:16][CH2:15][C:11]1([OH:14])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Reaktionsbedingungen
- Temperatur
- 60 °C
Versuchsvorschrift
To a solution of compound 25 (1.32 g, 5.30 mmol) in methanol (10 mL) under argon was added palladium hydroxide (20%) on activated charcoal (132 mg, 10% w/w). The solution was purged three times with hydrogen and stirred under hydrogen atmosphere at 60° C. for 4 hrs. The resulting solution was then filtered on celite plug to give desired compound 26 (790 mg, 94%) which was used as such for the next step.
Aufarbeitung
- customThe solution was purged three times with hydrogen
- filtrationThe resulting solution was then filtered on celite plug
Quellen und Nachweise
- ORD-Eintrag
- ord-46af2493455e4fd78c8c347dba57ef89
- Quelldatensatz
- uspto-grants-2012_05
- Patentnummer
- US08168627B2
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