4-[1,1,1,3,3,3-Hexafluoro-2-(methoxymethyl)oxypropan-2-yl]-2-propylphenyl benzyl ether → 4-(1,1,1,3,3,3-Hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propylphenol

HRID 1919753

Reaktionsgleichung

Reaktionsgleichung von HRID 1919753
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([O:24][CH2:25][O:26][CH3:27])([C:20]([F:23])([F:22])[F:21])[C:16]([F:19])([F:18])[F:17])=[CH:11][C:10]=1[CH2:28][CH2:29][CH3:30])C1C=CC=CC=1>[C].[Pd].CO>[F:17][C:16]([F:18])([F:19])[C:15]([C:12]1[CH:13]=[CH:14][C:9]([OH:8])=[C:10]([CH2:28][CH2:29][CH3:30])[CH:11]=1)([O:24][CH2:25][O:26][CH3:27])[C:20]([F:21])([F:23])[F:22]

Komponenten

4

Edukt 1

HCID 592011484-[1,1,1,3,3,3-Hexafluoro-2-(methoxymethyl)oxypropan-2-yl]-2-propylphenyl benzyl ether

Produkt 1

HCID 592010374-(1,1,1,3,3,3-Hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propylphenolAusbeute 104,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A 10% palladium carbon catalyst (30 mg) was added to a mixed solution of 4-[1,1,1,3,3,3-hexafluoro-2-(methoxymethyl)oxypropan-2-yl]-2-propylphenyl benzyl ether (264.9 mg, 0.61 mmol) in methanol (10 mL), followed by hydrogenation overnight. The catalyst was separated from the reaction solution by filtration, followed by concentration under reduced pressure to obtain 221.1 mg of the title compound (yield: 100%) as a pale yellow oil.

Aufarbeitung

  1. customThe catalyst was separated from the reaction solution by filtration
  2. concentrationfollowed by concentration under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-fa4bdb4d15b34aa0813217f1dea8373d
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08168666B2

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