1,1'-sulphonylbis-1H-imidazole → 4-Amino-5-ethoxy-1,2,3-benzoxathiazine 2,2-dioxide

HRID 1920713Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1920713
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([OH:10])[C:5]=1[C:11](=[NH:13])[NH2:12])[CH3:2].[S:14](N1C=CN=C1)(N1C=CN=C1)(=[O:16])=[O:15]>O>[NH2:13][C:11]1[C:5]2[C:4]([O:3][CH2:1][CH3:2])=[CH:9][CH:8]=[CH:7][C:6]=2[O:10][S:14](=[O:16])(=[O:15])[N:12]=1

Komponenten

4

Edukt 2

HCID 816091,1'-sulphonylbis-1H-imidazoleHCID 1360739132-Ethoxy-6-hydroxybenzenecarboximidamide

Produkt 1

HCID 462386994-Amino-5-ethoxy-1,2,3-benzoxathiazine 2,2-dioxide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

0.25 g (1.39 mmol) of 2-ethoxy-6-hydroxybenzenecarboximidamide is stirred without solvent with 0.65 g (3.28 mmol) of 1,1′-sulphonyldiimidazole at 130° C. for 18 hours. Cooling is followed by stirring the mixture with water and removing with dichloromethane. The organic phase is dried over magnesium sulphate and concentrated under reduced pressure. This gives 0.2 g of a pale yellow, crystalline material.

Aufarbeitung

  1. temperatureCooling
  2. customremoving with dichloromethane
  3. dry with materialThe organic phase is dried over magnesium sulphate
  4. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-db444358b5064ccea948f1c2d8203590
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08173641B2

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