Morpholine → HCID 59558570, Verbindung

HRID 1921321Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1921321
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:10]Br)=[C:6]([CH:9]=1)[C:7]#[N:8].[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.C(N(CC)CC)C>CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:10][N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[C:6]([CH:9]=1)[C:7]#[N:8]

Komponenten

5

Edukt 3

HCID 8083MorpholineHCID 8471TriethylamineHCID 442031405-Bromo-2-(bromomethyl)benzonitrile

Produkt 1

HCID 59558570HCID 59558570, VerbindungAusbeute 74,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

5-Bromo-2-bromomethylbenzonitrile (2.50 g, 9.1 mmol) is added portionwise to a stirred solution of morpholine (828 μL, 9.5 mmol) and triethylamine (1.27 mL, 9.1 mmol) in methanol (2 mL). After 4 hr, the solvent is removed and the residue is suspended in water that is made basic with sodium hydroxide and then extracted with ethyl acetate. The extract is dried, filtered, and concentrated to give 5-bromo-2-(morpholin-4-yl)methylbenzonitrile (1.90 g, 74%) as a cream solid.

Aufarbeitung

  1. customthe solvent is removed
  2. extractionextracted with ethyl acetate
  3. customThe extract is dried
  4. filtrationfiltered
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-97029078feef4f5a96ce09f9e59535e8
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08173682B2

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