Gamma-Aminobutyric Acid → Butanoic acid, 4-(benzoylamino)-

HRID 1921662

Reaktionsgleichung

Reaktionsgleichung von HRID 1921662
[NH2:1][CH2:2][CH2:3][CH2:4][C:5]([OH:7])=[O:6].[OH-].[Na+].[C:10](Cl)(=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.Cl>O>[C:10]([NH:1][CH2:2][CH2:3][CH2:4][C:5]([OH:7])=[O:6])(=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Komponenten

6

Edukt 4

HCID 119Gamma-Aminobutyric AcidHCID 313Hydrochloric AcidHCID 7412Benzoyl chlorideHCID 14798Sodium Hydroxide

Produkt 1

HCID 37118Butanoic acid, 4-(benzoylamino)-Ausbeute 74,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

6.4 g of gamma-aminobutyric acid and 4.5 g of sodium hydroxide were dissolved in 100 mL of purified water, and 7.9 g of benzoyl chloride was dropwise added thereto under ice-cooling. After stirring the mixture for 6 hours, hydrochloric acid was added to adjust the pH to 2 or less. The precipitated crude product was filtered, and then recrystallized with ethanol solution to give 8.7 g of the desired product.

Aufarbeitung

  1. temperatureunder ice-cooling
  2. customThe precipitated crude product
  3. filtrationwas filtered
  4. customrecrystallized with ethanol solution

Quellen und Nachweise

ORD-Eintrag
ord-bdf48983f8254f7ebce359772f7257cc
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08173705B2

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