Hydrogen Peroxide → HCID 59536621, Verbindung

HRID 1922174Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1922174
[OH:1]O.[CH3:3][O:4][C:5]1[CH:10]=[CH:9][C:8](B(O)O)=[C:7]([CH3:14])[N:6]=1.O>ClCCl>[CH3:3][O:4][C:5]1[N:6]=[C:7]([CH3:14])[C:8]([OH:1])=[CH:9][CH:10]=1

Komponenten

5

Edukt 3

HCID 784Hydrogen PeroxideHCID 962WaterHCID 27630842-Methyl-6-methoxypyridine-3-boronic acid

Produkt 1

HCID 59536621HCID 59536621, VerbindungAusbeute 62,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Add hydrogen peroxide (7.69 mL, 89.8 mmol) to a stirred mixture of 2-methoxy-6-methyl-5-pyridylboronic acid (5.0 g, 30 mmol) in dichloromethane (100 mL) kept under nitrogen at room temperature. Stir overnight at ambient temperature, add water and extract the mixture with dichloromethane. Combine the organic phases, dry (MgSO4), filter and concentrate to afford 2.6 g (62%) of the title compound. MS (m/z)=140 [M+1]

Aufarbeitung

  1. customkept under nitrogen at room temperature
  2. extractionextract the mixture with dichloromethane
  3. dry with materialdry (MgSO4)
  4. filtrationfilter
  5. concentrationconcentrate

Quellen und Nachweise

ORD-Eintrag
ord-15719b56bbb1479dae037ccbf7d0d6db
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08173821B2

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