Hydrochloric Acid → 1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-5-[3-(trifluoromethyl)-1H-pyrazol-1-yl]-2,4(1H,3H)-pyrimidinedione dihydrochloride

HRID 1925053Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1925053
[F:1][C:2]([F:36])([F:35])[C:3]1[CH:8]=[CH:7][C:6]([C@:9]23[CH2:14][C@H:13]2[CH2:12][N:11]([CH2:15][CH2:16][CH2:17][N:18]2[CH:23]=[C:22]([N:24]4[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[N:25]4)[C:21](=[O:33])[NH:20][C:19]2=[O:34])[CH2:10]3)=[CH:5][CH:4]=1.[ClH:37]>C(OCC)C>[ClH:37].[ClH:37].[F:36][C:2]([F:1])([F:35])[C:3]1[CH:4]=[CH:5][C:6]([C@:9]23[CH2:14][C@H:13]2[CH2:12][N:11]([CH2:15][CH2:16][CH2:17][N:18]2[CH:23]=[C:22]([N:24]4[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[N:25]4)[C:21](=[O:33])[NH:20][C:19]2=[O:34])[CH2:10]3)=[CH:7][CH:8]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 252531381-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-5-[3-(trifluoromethyl)-1H-pyrazol-1-yl]-2,4(1H,3H)-pyrimidinedione

Produkt 1

HCID 866443941-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-5-[3-(trifluoromethyl)-1H-pyrazol-1-yl]-2,4(1H,3H)-pyrimidinedione dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel2×

Versuchsvorschrift

1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-5-[3-(trifluoromethyl)-1H-pyrazol-1-yl]-2,4(1H,3H)-pyrimidinedione (E20, 10.3 mg, 0.020 mmol) was dissolved in Diethyl ether (2 ml). 1M solution of HCl in Diethyl ether (0.044 ml, 0.044 mmol) was added. The solvent was evaporated to obtain 11.6 mg of the title compound as a yellow powder.

Aufarbeitung

  1. customThe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-250f9fc8a58c45ffaffca7a4f1d89103
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08178549B2

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