Hydrazine hydrate (1:1) → 2-(6-Hydrazinylpyridin-3-yl)propan-2-ol
Reaktionsgleichung
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]([OH:11])([CH3:10])[CH3:9])=[CH:4][CH:3]=1.O.[NH2:13][NH2:14]>>[NH:13]([C:2]1[N:7]=[CH:6][C:5]([C:8]([OH:11])([CH3:10])[CH3:9])=[CH:4][CH:3]=1)[NH2:14]Komponenten
3
Reaktionsbedingungen
- Temperatur
- 110 °C
Versuchsvorschrift
A mixture of 2-(6-chloropyridin-3-yl)propan-2-ol (975 mg, 5.68 mmol), and hydrazine hydrate (5512 μl, 114 mmol) was heated in a microwave on high absorbance for 10 hr at 110° C. The mixture was cooled to room temperature and the hydrazine was removed via rotary evaporation. The resulting yellow residue was used without further work-up.
Aufarbeitung
- temperatureThe mixture was cooled to room temperature
- customthe hydrazine was removed via rotary evaporation
Quellen und Nachweise
- ORD-Eintrag
- ord-27ccae116e6240efa30b94b759b11845
- Quelldatensatz
- uspto-grants-2012_05
- Patentnummer
- US08178534B2
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