Ethylamine → HCID 59813867, Verbindung

HRID 1925294Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1925294
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[C:17]([F:29])=[C:18]2[C:23](=[CH:24][CH:25]=1)[C:22]([C:26](Cl)=[O:27])=[CH:21][CH:20]=[CH:19]2.[CH2:30]([NH2:32])[CH3:31]>C1COCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[C:17]([F:29])=[C:18]2[C:23](=[CH:24][CH:25]=1)[C:22]([C:26]([NH:32][CH2:30][CH3:31])=[O:27])=[CH:21][CH:20]=[CH:19]2

Komponenten

4

Edukt 2

HCID 6341EthylamineHCID 86608625HCID 86608625, Verbindung

Produkt 1

HCID 59813867HCID 59813867, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

6-(6,7-Dimethoxyquinolin-4-yloxy)-5-fluoro-1-naphthoyl chloride (70 mg) was stirred in a solution of 2M EtNH2 in THF (3 mL) at RT for 4 days. Solvent was evaporated and residue purified by prep plate using 5% MeOH in CH2Cl2 as the eluent. The solid obtained was rinsed with ether and dried to afford the title compound. MS (ESI pos. ion) m/z: 421.1 (M+H). Calc'd for C24H21FN2O4−420.43.

Aufarbeitung

  1. customSolvent was evaporated
  2. customresidue purified by prep plate
  3. customThe solid obtained
  4. washwas rinsed with ether
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-7557473bb5474e83816a0ed224db7e43
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08178557B2

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