Ethylamine → L-Theanine

HRID 1925779

Reaktionsgleichung

Reaktionsgleichung von HRID 1925779
CO[C:3]([CH2:5][CH2:6][C@H:7]([NH2:11])[C:8]([OH:10])=[O:9])=[O:4].C(CC(=O)C)(=O)C.[CH2:19]([N:23](CCCC)CCCC)[CH2:20]CC.C(N)C>CO>[NH2:11][C@H:7]([C:8]([OH:10])=[O:9])[CH2:6][CH2:5][C:3]([NH:23][CH2:19][CH3:20])=[O:4]

Komponenten

6

Edukt 4

HCID 6341EthylamineHCID 7622TributylamineHCID 31261AcetylacetoneHCID 686625-Methyl hydrogen L-glutamate

Produkt 1

HCID 439378L-TheanineAusbeute 66,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

First, 5.0 g (31 mmol) of L-glutamic acid-γ-methyl ester was suspended in 15 mL of methanol. To this, 3.4 g (34 mmol) of acetylacetone and 5.7 g (31 mmol) of tri-n-butylamine were added. The mixture was heated at 60° C. for 2 hours. Subsequently, 20 g (310 mmol) of 70% ethylamine was added to the mixture and the same procedure as in Example 1 was performed to obtain 3.6 g of theanine (yield: 66.7%). The obtained theanine had the same purity as high as in Example 1.

Quellen und Nachweise

ORD-Eintrag
ord-bf2f1eabb7e846139a59933d931e06a1
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08178722B2

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