Ethylamine → L-Theanine

HRID 1925780

Reaktionsgleichung

Reaktionsgleichung von HRID 1925780
CO[C:3]([CH2:5][CH2:6][C@H:7]([NH2:11])[C:8]([OH:10])=[O:9])=[O:4].C(C1CCCC1=O)(=O)C.[CH2:21]([N:23](CC)CC)[CH3:22].C(N)C>CO>[NH2:11][C@H:7]([C:8]([OH:10])=[O:9])[CH2:6][CH2:5][C:3]([NH:23][CH2:21][CH3:22])=[O:4]

Komponenten

6

Edukt 4

HCID 6341EthylamineHCID 8471TriethylamineHCID 686625-Methyl hydrogen L-glutamateHCID 984712-Acetylcyclopentanone

Produkt 1

HCID 439378L-TheanineAusbeute 66,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

First, 5.0 g (31 mmol) of L-glutamic acid-γ-methyl ester was suspended in 15 mL of methanol. To this, 4.3 g (34 mmol) of 2-acetyl-cyclopentanone and 3.1 g (31 mmol) of triethylamine were added. The mixture was heated at 60° C. for 2 hours. Subsequently, 20 g (310 mmol) of 70% ethylamine was added to the mixture and the same procedure as in Example 1 was performed to obtain 3.6 g of theanine (yield: 66.7%). The obtained theanine had the same purity as high as in Example 1.

Quellen und Nachweise

ORD-Eintrag
ord-578b4314d3964a6ab643672c3e142ed7
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08178722B2

Verknüpfte Notizen

Wird geladen…