HCID 44540433, Verbindung → HCID 44540435, Verbindung

HRID 1926203Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1926203
[N+:1]([C:4]1[CH:16]=[CH:15][C:14]2[C:13]3[C:8](=[CH:9][C:10]([N+:17]([O-])=O)=[CH:11][CH:12]=3)[C:7](=[CH:20][C:21]([NH:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][C:29]([NH:31][C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=3[NH2:38])=[O:30])=[O:22])[C:6]=2[CH:5]=1)([O-])=O.[H][H]>CO.[Pd]>[NH2:17][C:10]1[CH:11]=[CH:12][C:13]2[C:14]3[C:6](=[CH:5][C:4]([NH2:1])=[CH:16][CH:15]=3)[C:7](=[CH:20][C:21]([NH:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][C:29]([NH:31][C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=3[NH2:38])=[O:30])=[O:22])[C:8]=2[CH:9]=1

Komponenten

5

Edukt 2

HCID 44540433HCID 44540433, VerbindungHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 44540435HCID 44540435, VerbindungAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 6-(2-(2,7-dinitro-9H-fluoren-9-ylidene)acetamido)-N-(2-aminophenyl)-hexanamide (515 mg, 1 mmol) in methanol (20 ml) was added 5% palladium on charcoal (0.50 g). Then the mixture was stirred under an atmosphere of hydrogen at room temperature until hydrogen uptake ceased. The solution was filtered through celite, and the filtrate was evaporated under vacuum to give the title compound (437 mg, 96% yield) as a white solid. LC-MS (m/z) 456 (M+1).

Aufarbeitung

  1. filtrationThe solution was filtered through celite
  2. customthe filtrate was evaporated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-ddb350a83df84cd4b31e0e66bffcfcb5
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08178577B2

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