Water → Methyl-5-oxo-4,5-dihydropyrazolo[1,5-a]quinazoline-3-carboxylate

HRID 1927291Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1927291
Cl.[NH:2]([C:4]1[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=O)[NH2:3].[CH2:13]([O:15][CH:16]=[C:17]([C:20]#N)[C:18]#[N:19])C.[O-:22]CC.[Na+].O>CCO>[CH3:13][O:15][C:16]([C:17]1[CH:20]=[N:3][N:2]2[C:4]3[C:5](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:6](=[O:8])[NH:19][C:18]=12)=[O:22]

Komponenten

6

Edukt 4

HCID 962WaterHCID 671522-(Ethoxymethylene)propanedinitrileHCID 104169Benzoic acid, 2-hydrazinyl-, hydrochloride (1:1)HCID 2723922Sodium ethoxide

Produkt 1

HCID 136389266Methyl-5-oxo-4,5-dihydropyrazolo[1,5-a]quinazoline-3-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 2-hydrazinylbenzoic acid hydrochloride (10 g, 53 mmol), 2-(ethoxymethylene)malononitrile (6.5 g, 53.2 mmol) and sodium ethoxide (4.85 g, 257 mmol) in EtOH (100 mL) was refluxed overnight then cooled to ambient temperature. Water was added and the mixture was stirred at ambient temperature for 1 h then filtered. The solid was washed with H2O, EtOH and Et2O then dried.

Aufarbeitung

  1. temperaturewas refluxed overnight
  2. filtrationthen filtered
  3. washThe solid was washed with H2O, EtOH and Et2O
  4. customthen dried

Quellen und Nachweise

ORD-Eintrag
ord-391fcd7d3502490dbc94dbabb9bbe8a3
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08183250B2

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