Sodium Sulfite → HCID 178506558, Verbindung

HRID 1927684Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1927684
[I:1][C:2]1[N:3]=[C:4]([CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)=[CH:12][CH:11]=2)[NH:5][C:6]=1I.S([O-])([O-])=O.[Na+].[Na+]>C(O)C.O>[I:1][C:2]1[N:3]=[C:4]([CH2:8][CH2:9][C:10]2[CH:11]=[CH:12][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)=[CH:14][CH:15]=2)[NH:5][CH:6]=1

Komponenten

5

Edukt 2

HCID 24437Sodium SulfiteHCID 686726842-[4-[2-(4,5-diiodo-1H-imidazol-2-yl)ethyl]phenyl]pyridine

Produkt 1

HCID 178506558HCID 178506558, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 2-{4-[2-(4,5-diiodo-1H-imidazol-2-yl)ethyl]phenyl}pyridine (11.2 g, 22.4 mmol) and sodium sulfite (3.1 g, 24.7 mmol) in ethanol (200 mL) and water (200 mL) was heated at 100° C. for 2 days. The reaction mixture was concentrated to half its original volume and partitioned between ethyl acetate and water. The organic phase was separated and concentrated in vacuo to afford 2-{4-[2-(4-iodo-1H-imidazol-2-yl)ethyl]phenyl}pyridine, which was used without further purification.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated to half its original volume
  2. custompartitioned between ethyl acetate and water
  3. customThe organic phase was separated
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-7e1f3486b3574dbf93eccbfcd40d8f67
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08183275B2

Notizen zur Reaktion

Wird geladen…