HCID 178418361, Verbindung → HCID 178501606, Verbindung

HRID 19300Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 19300
[CH3:1][O:2][C:3](=[O:22])/[C:4](/[NH:11]C(OCC1C=CC=CC=1)=O)=[CH:5]/[C@H:6]1[CH2:9][C@H:8]([CH3:10])[CH2:7]1.[H][H]>[Pd].CO>[CH3:1][O:2][C:3](=[O:22])[CH:4]([NH2:11])[CH2:5][C@H:6]1[CH2:7][C@H:8]([CH3:10])[CH2:9]1

Komponenten

5

Edukt 2

HCID 178418361HCID 178418361, VerbindungHCID 178500468HCID 178500468, Verbindung

Produkt 1

HCID 178501606HCID 178501606, VerbindungAusbeute 87,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

In a Parr shaker bottle was placed (Z)-2-benzyloxycarbonylamino-3-(trans-3-methyl-cyclobutyl)-acrylic acid methyl ester (300 mg, 0.99 mmol), methanol (10 mL) and 10% palladium on activated carbon (60 mg). The mixture was placed on the Parr hydrogenator and charged with 40 psi hydrogen pressure and shaken for 1.5 h. After such time, the catalyst was filtered off through a plug of celite and the filterate concentrated in vacuo to afford 2-amino-3-(trans-3-methyl-cyclobutyl)-propionic acid methyl ester (148 mg, 87%) as a pale yellow oil.

Aufarbeitung

  1. filtrationAfter such time, the catalyst was filtered off through a plug of celite
  2. concentrationthe filterate concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-93df58aa04ce436498a50dd4958b3876
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741327B2

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