Acetic Anhydride → 1-(4-benzyl-2-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)ethanone

HRID 1930711Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1930711
[C:1](OC(=O)C)(=[O:3])[CH3:2].[CH2:8]([C:15]1[C:16]2[CH2:39][NH:38][CH2:37][CH2:36][C:17]=2[N:18]=[C:19]([NH:21][C:22]2[CH:27]=[CH:26][C:25]([N:28]3[CH:32]=[C:31]([CH3:33])[N:30]=[CH:29]3)=[C:24]([O:34][CH3:35])[CH:23]=2)[N:20]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>C1COCC1>[CH2:8]([C:15]1[C:16]2[CH2:39][N:38]([C:1](=[O:3])[CH3:2])[CH2:37][CH2:36][C:17]=2[N:18]=[C:19]([NH:21][C:22]2[CH:27]=[CH:26][C:25]([N:28]3[CH:32]=[C:31]([CH3:33])[N:30]=[CH:29]3)=[C:24]([O:34][CH3:35])[CH:23]=2)[N:20]=1)[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 593336984-Benzyl-N-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine

Produkt 1

HCID 593337471-(4-benzyl-2-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)ethanoneAusbeute 33,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Acetic anhydride (0.039 mL, 0.41 mmol) was added to a solution of 4-benzyl-N-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine (175 mg, 0.41 mmol, example 109) in THF (3 mL) and stirred for one hour. The solvent was evaporated under reduced pressure and the crude product purified on prepHPLC yielding 1-(4-benzyl-2-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)ethanone (64.0 mg, 33.3%).

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure
  2. customthe crude product purified

Quellen und Nachweise

ORD-Eintrag
ord-a6dbd0a427d644208dc39cac8b71494b
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08188101B2

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