HCID 18738443, Verbindung → HCID 18738434, Verbindung
Reaktionsgleichung
[N:1]1([S:7]([CH2:10][C@H:11]([CH3:22])[C:12]([O:14]CC2C=CC=CC=2)=[O:13])(=[O:9])=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>[Pd]>[N:1]1([S:7]([CH2:10][C@H:11]([CH3:22])[C:12]([OH:14])=[O:13])(=[O:9])=[O:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1Komponenten
3
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A 100 mL Fisher/Porter vessel was charged with 1 g of benzyl 3-(1-piperidinyl)sulfonyl-2(R)-methylpropionate 30 mL MeOH and a catalytic amount of 10% Pd—C. The reaction was hydrogenated at 50 psi for 3 hours. After filtration through Celite and concentration in vacuo of 3-(1-piperidinyl)sulfonyl-2(R)-methylpropionic acid was isolated in quantitive yield.
Aufarbeitung
- filtrationAfter filtration
- concentrationthrough Celite and concentration in vacuo of 3-(1-piperidinyl)sulfonyl-2(R)-methylpropionic acid
- customwas isolated in quantitive yield
Quellen und Nachweise
- ORD-Eintrag
- ord-dcef4994de94407c8aed218d4fcaf97a
- Quelldatensatz
- uspto-grants-2002_05
- Patentnummer
- US06384036B1
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