Acetic Anhydride → HCID 54312022, Verbindung

HRID 1935457Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1935457
[C:1]([O:4][C:5](=O)C)(=O)[CH3:2].[NH2:8][C:9]1[S:18][C:12]2[CH2:13][N:14]([CH3:17])[CH2:15][CH2:16][C:11]=2[C:10]=1[C:19]([O:21][CH2:22][CH3:23])=[O:20]>C(OCC)(OCC)OCC>[CH2:1]([O:4][CH:5]=[N:8][C:9]1[S:18][C:12]2[CH2:13][N:14]([CH3:17])[CH2:15][CH2:16][C:11]=2[C:10]=1[C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH3:2]

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 207319ethyl 2-amino-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate

Produkt 1

HCID 54312022HCID 54312022, VerbindungAusbeute 97 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 31214Ethyl orthoformateLösungsmittel

Versuchsvorschrift

3.2 ml of acetic anhydride were added to 40.0 g (167 mmol) of 5 2-amino-3-carboethoxy-6-methyl-4,5,6,7-tetrahydrothieno-[2,3-c]pyridine in 250 ml of triethyl orthoformate and the mixture was boiled under nitrogen and at reflux for 3 h. After that, the mixture was evaporated right down at 80° C. on a rotary evaporator. 48.0 g (97%) of crude product were isolated as a dark oil, which is sufficiently pure for further reaction.

Aufarbeitung

  1. temperatureat reflux for 3 h
  2. customAfter that, the mixture was evaporated right down at 80° C. on a rotary evaporator

Quellen und Nachweise

ORD-Eintrag
ord-c9ed9e74f02f4561a006b721d6a72a68
Quelldatensatz
uspto-grants-2002_05
Patentnummer
US06387912B1

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