2,3-Diphenylpropionic acid → 2-Phenyl-2,3-dihydro-1H-inden-1-one

HRID 1935740

Reaktionsgleichung

Reaktionsgleichung von HRID 1935740
[C:1]1([CH:7]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8]([OH:10])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>O>[C:1]1([CH:7]2[CH2:11][C:12]3[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:8]2=[O:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

3

Edukt 1

HCID 187442,3-Diphenylpropionic acid

Produkt 1

HCID 3184912-Phenyl-2,3-dihydro-1H-inden-1-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Polyphosphoric acid (50 g) was heated in an oil bath at 140-145° C. and 2,3-diphenyl-propanoic acid (2.5 g) was added. Heating was continued for 45 min. Water was added. The mixture was cooled and extracted with ethyl acetate. The organic extracts were washed with 1 M NaOH solution and water. After drying the solvent was evaporated under reduced pressure. The product thus obtained was further purified by trituration in heptane.

Aufarbeitung

  1. temperatureHeating
  2. temperatureThe mixture was cooled
  3. extractionextracted with ethyl acetate
  4. washThe organic extracts were washed with 1 M NaOH solution and water
  5. customAfter drying the solvent
  6. customwas evaporated under reduced pressure
  7. customThe product thus obtained
  8. customwas further purified by trituration in heptane

Quellen und Nachweise

ORD-Eintrag
ord-936efe47068f487a8c3449ba258d1285
Quelldatensatz
uspto-grants-2002_05
Patentnummer
US06388090B2

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