Reaktionsgleichung
C=[CH:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Cl.CN(C)CCCN=C=NCC.C1(CC(O)=[O:29])C=CC=CC=1.C[N:32]([CH:34]=[O:35])C>>[OH:29][NH:32][C:34](=[O:35])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1Komponenten
Versuchsvorschrift
To a suspension of the 4-(methyl-O-methylhydroxylamine)-2-fluorophenoxymethyl-copoly(styrene-1% divinylbenzene)resin (0.10 g, 0.14 mmol) in dry DMF (2 ml) is added 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (0.08 g, 0.42 mmol, 3 eq.). To the mixture is then added phenylacetic acid (0.06 g, 0.42 mmol, 3 eq.). The mixture is shaken overnight. The resin is filtered and washed with DMF (×5), THF: H2O (3:1, ×5), THF (×3), MeOH (×3) and DCM (×3). To the resin is added TFA (1 ml) and DCM (1 ml) and the mixture shaken for 1 hour. The mixture is filtered into a tared vial and the resin washed with DCM (×2) and toluene (×2). The combined filtrates are evaporated in vacuo to yield N-hydroxy-phenyl-acetamide (0.0084 g, 39%). LCMS gives 151 [M+].
Aufarbeitung
- filtrationThe resin is filtered
- washwashed with DMF (×5), THF: H2O (3:1, ×5), THF (×3), MeOH (×3) and DCM (×3)
- additionTo the resin is added TFA (1 ml) and DCM (1 ml)
- stirringthe mixture shaken for 1 hour
- filtrationThe mixture is filtered into a tared vial and the resin
- washwashed with DCM (×2) and toluene (×2)
- customThe combined filtrates are evaporated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-5bf10fc4d4e54836a3efba8ef0e475dd
- Quelldatensatz
- uspto-grants-2002_05
- Patentnummer
- US06392010B1
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