Tetrahydrofuran → 3-Phenyl-7-[[6-(4-hydroxybutylbutylamino)-4-diethylamino-s-triazine-2-yl]amino]coumarin

HRID 1938134

Reaktionsgleichung

Reaktionsgleichung von HRID 1938134
[C:1]1([C:7]2[C:8](=[O:30])[O:9][C:10]3[C:15]([CH:16]=2)=[CH:14][CH:13]=[C:12]([NH:17][C:18]2[N:23]=[C:22]([N:24]([CH2:27][CH3:28])[CH2:25][CH3:26])[N:21]=[C:20](Cl)[N:19]=2)[CH:11]=3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:31]([NH:35][CH2:36][CH2:37][CH2:38][CH2:39][OH:40])[CH2:32][CH2:33][CH3:34].O1CCCC1>O>[C:1]1([C:7]2[C:8](=[O:30])[O:9][C:10]3[C:15]([CH:16]=2)=[CH:14][CH:13]=[C:12]([NH:17][C:18]2[N:23]=[C:22]([N:24]([CH2:27][CH3:28])[CH2:25][CH3:26])[N:21]=[C:20]([N:35]([CH2:36][CH2:37][CH2:38][CH2:39][OH:40])[CH2:31][CH2:32][CH2:33][CH3:34])[N:19]=2)[CH:11]=3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

5

Edukt 3

HCID 8028TetrahydrofuranHCID 206691-Butanol, 4-(butylamino)-HCID 796502H-1-Benzopyran-2-one, 7-[[4-chloro-6-(diethylamino)-1,3,5-triazin-2-yl]amino]-3-phenyl-

Produkt 1

HCID 214684943-Phenyl-7-[[6-(4-hydroxybutylbutylamino)-4-diethylamino-s-triazine-2-yl]amino]coumarin

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

21.1 Parts of 3-phenyl-7-[(6-chloro-4-diethylamino-s-triazine-2-yl)amino]coumarin and 14.2 parts of N-butylamino-4-butanol were added to 20 parts of tetrahydrofuran and reacted for 6 hours under reflux. The reaction product was poured into water, and the crystals thus precipitated were collected by filtration. The product was recrystallized from a mixed solvent of chloroform:ethyl acetate (1:1 by volume) to obtain 20 parts of 3-phenyl-7-[[6-(4-hydroxybutylbutylamino)-4-diethylamino-s-triazine-2-yl]amino]coumarin. The resulting compound had a melting point of from 124° to 126° C.

Aufarbeitung

  1. customreacted for 6 hours
  2. temperatureunder reflux
  3. customthe crystals thus precipitated
  4. filtrationwere collected by filtration
  5. customThe product was recrystallized from a mixed solvent of chloroform:ethyl acetate (1:1 by volume)

Quellen und Nachweise

ORD-Eintrag
ord-65121c9120cf4f258076bf730c16f692
Quelldatensatz
uspto-grants-1997_12
Patentnummer
US05693436

Verknüpfte Notizen

Wird geladen…