Dicyclohexylcarbodiimide → 2-[4-[2-(2H-tetrazol-5-yl)benzamido]-1H-benzimidazol-1-yl]octanoic acid

HRID 1938603Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1938603
[N+:1]([C:4]1[C:12]2[N:11]=[CH:10][N:9]([CH:13]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[C:14]([O:16]CC)=[O:15])[C:8]=2[CH:7]=[CH:6][CH:5]=1)([O-])=O.[N:25]1[NH:26][N:27]=[N:28][C:29]=1[C:30]1[CH:38]=[CH:37][CH:36]=[CH:35][C:31]=1[C:32](O)=[O:33].C1(N=C=NC2CCCCC2)CCCCC1.OC1C2N=NNC=2C=CC=1>C(O)C.CN(C=O)C.[Pd]>[N:28]1[NH:27][N:26]=[N:25][C:29]=1[C:30]1[CH:38]=[CH:37][CH:36]=[CH:35][C:31]=1[C:32]([NH:1][C:4]1[C:12]2[N:11]=[CH:10][N:9]([CH:13]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[C:14]([OH:16])=[O:15])[C:8]=2[CH:7]=[CH:6][CH:5]=1)=[O:33]

Komponenten

8

Edukt 4

HCID 10868DicyclohexylcarbodiimideHCID 5551922-(1H-1,2,3,4-tetrazol-5-yl)benzoic acidHCID 21468887Ethyl 2-(4-nitro-1H-benzimidazol-1-yl)octanoateHCID 178418300HCID 178418300, Verbindung

Produkt 1

HCID 214689902-[4-[2-(2H-tetrazol-5-yl)benzamido]-1H-benzimidazol-1-yl]octanoic acidAusbeute 9,6 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

Ethyl 2-(4-nitro-1H-benzimidazol-1-yl)octanoate (4.44 mmoles, 1.48 g.) was hydrogenated over 0.6 g of 5% Pd/C in 100 ml ethanol. The catalyst was filtered over celite. The solution was concentrated. The residue was dissolved in 25 ml DMF and added to a stirred mixture of 2-(2H-tetrazol-5-yl)benzoic acid (4.21 mmoles, 0.80 g), dicyclohexylcarbodiimide (4.31 mmoles, 0.89 g.), and hydroxybenzotriazole (4.44 mmoles, 0.60 g) in 50 ml DMF. The reaction was stirred for 4 hours. The solid was removed by filtration. The reaction was concentrated. The residue was dissolved in ethyl acetate, and washed with water. The pH was adjusted to 8.0 using 5N NaOH. The aqueous layer was acidified to pH 2.5 using 2N HCL, and then extracted with ethyl acetate. The organic phase was separated, washed with water, dried and concentrated. The product was purified over silica gel eluted with 2% EtOH in ethyl acetate with 1% acetic acid to yield 0.18 g of 2-[4-[2-(2H-tetrazol-5-yl)benzamido]-1H-benzimidazol-1-yl]octanoic acid. (MS)

Aufarbeitung

  1. filtrationThe catalyst was filtered over celite
  2. concentrationThe solution was concentrated
  3. dissolutionThe residue was dissolved in 25 ml DMF
  4. customThe solid was removed by filtration
  5. concentrationThe reaction was concentrated
  6. dissolutionThe residue was dissolved in ethyl acetate
  7. washwashed with water
  8. extractionextracted with ethyl acetate
  9. customThe organic phase was separated
  10. washwashed with water
  11. customdried
  12. concentrationconcentrated
  13. customThe product was purified over silica gel
  14. washeluted with 2% EtOH in ethyl acetate with 1% acetic acid

Quellen und Nachweise

ORD-Eintrag
ord-164421251f2e46e1ab01007e22c7d6b5
Quelldatensatz
uspto-grants-1997_12
Patentnummer
US05693633

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