Glycine → HCID 178446845, Verbindung

HRID 1939643

Reaktionsgleichung

Reaktionsgleichung von HRID 1939643
[NH2:1][CH2:2][C:3]([OH:5])=[O:4].[OH-].[Na+].[C:8](=[NH:15])(OC)[CH2:9][CH2:10][CH2:11][CH3:12]>CO.O.C1(C)C=CC=CC=1>[C:8]([NH:1][CH2:2][C:3]([OH:5])=[O:4])(=[NH:15])[CH2:9][CH2:10][CH2:11][CH3:12]

Komponenten

7

Edukt 3

HCID 750GlycineHCID 14798Sodium HydroxideHCID 5743466Methyl pentanimidate

Produkt 1

HCID 178446845HCID 178446845, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittelHCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

A stirred suspension of glycine (18.77 g, 0.25 mol) in methanol (80 ml) and water (4.5 ml) was cooled to 0° C. and adjusted to pH 9.6 by adding 30 percent strength sodium hydroxide solution. Methyl pentanimidate (68.81 g of a 42 percent strength solution in toluene=0.25 mol) was added to this suspension over the course of 5 minutes. After stirring for 18 hours at room temperature, the suspension was filtered, and the filter cake was washed with toluene (75 ml) and dried. The yield of the title compound was 25.45 g (purity>95 percent by H-NMR), 64 percent based on glycine. Other data concerning the title compound was:

Aufarbeitung

  1. filtrationthe suspension was filtered
  2. washthe filter cake was washed with toluene (75 ml)
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-29a4371eaa2e4314b849bb321c42dbc2
Quelldatensatz
uspto-grants-1997_12
Patentnummer
US05696272

Verknüpfte Notizen

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