Hydrochloric Acid → 3-Oxo-4-phenyl-3,4-dihydropyrido[2,3-b]pyrazine-2-carboxylic acid

HRID 1942136Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1942136
[O:1]=[C:2]1[N:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:6]2[N:14]=[CH:15][CH:16]=[CH:17][C:5]=2[N:4]=[C:3]1[C:18]([O:20]CC)=[O:19].Cl>C(O)(=O)C>[O:1]=[C:2]1[N:7]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:6]2[N:14]=[CH:15][CH:16]=[CH:17][C:5]=2[N:4]=[C:3]1[C:18]([OH:20])=[O:19]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 68476438HCID 68476438, Verbindung

Produkt 1

HCID 675319973-Oxo-4-phenyl-3,4-dihydropyrido[2,3-b]pyrazine-2-carboxylic acidAusbeute 67,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

10.74 g (36 mmol) of ethyl 3-oxo-4-phenyl-3,4-dihydropyrido[2,3-b]pyrazine-2-carboxylate was dissolved in acetic acid (270 mL), and 6 N hydrochloric acid (80 mL) was added thereto at room temperature. Then, the mixture was stirred overnight at room temperature. After confirming the completion of the reaction, the solvent was distilled off under reduced pressure, and water (100 mL) was added. The solid thus obtained was separated by filtration and dried, to obtain 6.50 g (yield: 67%) of 3-oxo-4-phenyl-3,4-dihydropyrido[2,3-b]pyrazine-2-carboxylic acid as pale brown crystals.

Aufarbeitung

  1. customat room temperature
  2. customthe completion of the reaction
  3. distillationthe solvent was distilled off under reduced pressure, and water (100 mL)
  4. additionwas added
  5. customThe solid thus obtained
  6. customwas separated by filtration
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-64d48a0cda3748a48766773d50c82dc2
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08389523B2

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