Acetic Acid → Phenoxyacetaldehyde

HRID 1942441

Reaktionsgleichung

Reaktionsgleichung von HRID 1942441
C([O:3][CH:4](OCC)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)C.C(O)(=O)C.Cl>C(O)C>[O:6]([CH2:5][CH:4]=[O:3])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 96328(2,2-Diethoxyethoxy)benzene

Produkt 1

HCID 75033Phenoxyacetaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

0.84 g (4 mmol) of 69A, 5 mL of acetic acid, 2.5 mL of 1N aqueous hydrochloric acid and 20 mL of ethanol were mixed and heated under reflux under an argon atmosphere for 3 hours. Ethanol was evaporated. Then the resulting residue was dispersed in dichloromethane and extracted with saturated sodium bicarbonate solution. The organic phase was dried with sodium sulfate and the solvent evaporated in vacuum. The crude product was obtained in almost quantitative yield.

Aufarbeitung

  1. temperatureheated
  2. temperatureunder reflux under an argon atmosphere for 3 hours
  3. customEthanol was evaporated
  4. additionThen the resulting residue was dispersed in dichloromethane
  5. extractionextracted with saturated sodium bicarbonate solution
  6. dry with materialThe organic phase was dried with sodium sulfate
  7. customthe solvent evaporated in vacuum

Quellen und Nachweise

ORD-Eintrag
ord-2ec187ccb9594cdb8a00a7050c53f9f6
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08389555B2

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