HCID 178418361, Verbindung → HCID 178461433, Verbindung

HRID 1943913Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1943913
[CH3:1][C@H:2]1[CH2:4][C@H:3]1[C:5]1[C:13]2[C:8](=[N:9][CH:10]=[C:11]([N+:14]([O-])=O)[CH:12]=2)[NH:7][N:6]=1.[H][H]>CO.[Pd]>[CH3:1][C@H:2]1[CH2:4][C@H:3]1[C:5]1[C:13]2[C:8](=[N:9][CH:10]=[C:11]([NH2:14])[CH:12]=2)[NH:7][N:6]=1

Komponenten

5

Edukt 2

HCID 178418361HCID 178418361, VerbindungHCID 178461434HCID 178461434, Verbindung

Produkt 1

HCID 178461433HCID 178461433, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

3-(cis-2-Methylcyclopropyl)-5-nitro-1H-pyrazolo[3,4-b]pyridine (0.0462 g, 0.212 mmol) and Pd/C were taken up in MeOH. Hydrogen gas was passed through for 10 minutes, and the reaction mixture was stirred under a hydrogen atmosphere for 20 minutes. The solution was filtered through celite and concentrated to provide 3-(cis-2-methylcyclopropyl)-1H-pyrazolo[3,4-b]pyridin-5-amine as an oil, which was used without further purification.

Aufarbeitung

  1. customwas passed through for 10 minutes
  2. filtrationThe solution was filtered through celite and
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-98e2f883c1334237b6a9accd73e75a67
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08394795B2

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