Dimethyl Sulfoxide → 3-(Pyridine-3-sulfonyl)thiophene-2-carbaldehyde

HRID 1944434Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1944434
Cl[C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH:7]=[O:8].[Na+].[N:10]1[CH:15]=[CH:14][CH:13]=[C:12]([S:16]([O-:18])=[O:17])[CH:11]=1.CS(C)=O>O>[N:10]1[CH:15]=[CH:14][CH:13]=[C:12]([S:16]([C:2]2[CH:6]=[CH:5][S:4][C:3]=2[CH:7]=[O:8])(=[O:18])=[O:17])[CH:11]=1

Komponenten

5

Edukt 3

HCID 679Dimethyl SulfoxideHCID 27358253-Chlorothiophene-2-carbaldehydeHCID 23697071Sodium pyridine-3-sulfinate

Produkt 1

HCID 866521933-(Pyridine-3-sulfonyl)thiophene-2-carbaldehydeAusbeute 28,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A mixture of 3-chlorothiophene-2-carbaldehyde (0.16 g), pyridine-3-sulfinic acid sodium salt (0.30 g) and dimethyl sulfoxide (2.0 mL) was heated at 80° C. for 3 hours and then at 90° C. for 3 hours. The mixture was diluted with water, extracted with ethyl acetate and the combined organic extract was dried over magnesium sulfate. The solvent was removed under reduced pressure to afford the title compound as a grey solid (0.079 g).

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. extractionthe combined organic extract
  3. dry with materialwas dried over magnesium sulfate
  4. customThe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-0017927d9ad14a2eb52085da64a7ee85
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08394836B2

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