1-Benzyl-4-((6-((tert-butyldimethylsilyl)oxy)hexyl)oxy)piperidine → HCID 58505168, Verbindung

HRID 1944858Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1944858
C([N:8]1[CH2:13][CH2:12][CH:11]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:21][Si:22]([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:24])[CH3:23])[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[Si:22]([O:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][O:14][CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:24])[CH3:23]

Komponenten

5

Edukt 2

HCID 575169301-Benzyl-4-((6-((tert-butyldimethylsilyl)oxy)hexyl)oxy)piperidineHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 58505168HCID 58505168, VerbindungAusbeute 98,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

Intermediate 22 (157 mg, 0.387 mmol) was dissolved in MeOH (5 mL) then added 10% (w/w) Pd/C (41 mg, 0.0387 mmol). The reaction vessel was attached to 3-way valve with balloon containing hydrogen gas. The vessel was evacuated 3 times then back flushed with hydrogen. The resulting suspension was stirred overnight, filtered, and concentrated to give the title compound (120 mg) as clear oil. The compound was used with no further purification. ES/MS calcd for C17H38NO2Si+ 316.3. Found m/z=316.3 (M+H)+.

Aufarbeitung

  1. customThe reaction vessel was attached to 3-way valve with balloon
  2. customThe vessel was evacuated 3 times
  3. customthen back flushed with hydrogen
  4. filtrationfiltered
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-3fbf310c0dfe43c58cab7d547eaeb997
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08394829B2

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