Water → N-diphenylmethylsarcosine

HRID 19465

Reaktionsgleichung

[NH:1]([CH2:3][C:4]([OH:6])=[O:5])[CH3:2].[OH-].[K+].Cl[CH:10]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.O>C(O)(C)C>[C:11]1([CH:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[N:1]([CH2:3][C:4]([OH:6])=[O:5])[CH3:2])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Komponenten

Reaktionsbedingungen

Temperatur: 50 °C

Versuchsvorschrift

In a 250 ml three-necked flask equipped with a magnetic stirrer, a thermometer, a dropping funnel and a condenser, a mixture of sarcosine (4.45 g; 50 mmol) and KOH (8.47 g; 151 mmol) in 70 ml of isopropanol is prepared by heating the mixture to 50° C. The medium remains cloudy after 30 minutes then chlorodiphenylmethane (10.7 ml; 60 mmol) is added over 30 minutes at 50° C. The mixture is heated for 5 hours at this temperature. The mixture is then left to cool down to ambient temperature. After the addition of 100 ml of water, the pH is adjusted to 10 and the chlorodiphenylmethane which has not reacted is recovered after extraction with CHCl3. The pH is adjusted to 5-6 with concentrated HCl and the mixture is extracted once again with chloroform in order to produce 2.23 g of product (Yield=18%) in the form of colourless gum.

Aufarbeitung

customIn a 250 ml three-necked flask equipped with a magnetic stirrer
customis prepared
temperatureThe mixture is heated for 5 hours at this temperature
waitThe mixture is then left
temperatureto cool down to ambient temperature
customis recovered
extractionafter extraction with CHCl3
extractionthe mixture is extracted once again with chloroform in order

Quellen und Nachweise

ORD-Eintrag: ord-275f00cdf8654295becbc7c5269b4d1b
Quelldatensatz: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07745413B2

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