Acetic Anhydride → N-{1-[1-(4-Chloro-benzoyl)-4-hydroxy-pyrrolidin-3-yl]-piperidin-4-yl}-N-(4-chloro-phenyl)-acetamide

HRID 1947107Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1947107
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:14][CH:13]([OH:15])[CH:12]([N:16]3[CH2:21][CH2:20][CH:19]([NH:22][C:23]4[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=4)[CH2:18][CH2:17]3)[CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[CH3:30][C:31](OC(C)=O)=[O:32]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([N:10]2[CH2:14][CH:13]([OH:15])[CH:12]([N:16]3[CH2:17][CH2:18][CH:19]([N:22]([C:23]4[CH:24]=[CH:25][C:26]([Cl:29])=[CH:27][CH:28]=4)[C:31](=[O:32])[CH3:30])[CH2:20][CH2:21]3)[CH2:11]2)=[O:9])=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 68512735HCID 68512735, Verbindung

Produkt 1

HCID 68511424N-{1-[1-(4-Chloro-benzoyl)-4-hydroxy-pyrrolidin-3-yl]-piperidin-4-yl}-N-(4-chloro-phenyl)-acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

The starting materials (4-Chloro-phenyl)-{3-[4-(4-chloro-phenylamino)-piperidin-1-yl]-4-hydroxy-pyrrolidin-1-yl}-methanone (48 mg, 0.11 mmol) and Ac2O (16 uL, 0.17 mmol) were added in pyridine (0.5 mL) and stirred at room temperature overnight. The reaction mixture was concentrated down to dryness. The resulting crude residue was purified by column chromatography on silica (Methanol\CH2Cl2: 0%-6%).

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated down to dryness
  2. customThe resulting crude residue was purified by column chromatography on silica (Methanol\CH2Cl2: 0%-6%)

Quellen und Nachweise

ORD-Eintrag
ord-3333f31298cb4404aff230367e97c5d5
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08399455B2

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