Sodium Methoxide → HCID 57562885, Verbindung

Reaktionsgleichung

[NH2:1][S:2]([C:5]1[CH:6]=[C:7]([N+:13]([O-:15])=[O:14])[CH:8]=[C:9]([CH3:12])[C:10]=1F)(=[O:4])=[O:3].[CH3:16][O-:17].[Na+]>>[NH2:1][S:2]([C:5]1[CH:6]=[C:7]([N+:13]([O-:15])=[O:14])[CH:8]=[C:9]([CH3:12])[C:10]=1[O:17][CH3:16])(=[O:4])=[O:3]

Komponenten

Edukt 2

HCID 10942334Sodium Methoxide

HCID 57562895HCID 57562895, Verbindung

Produkt 1

HCID 57562885HCID 57562885, Verbindung

Versuchsvorschrift

The resulting 3-aminosulfonyl-4-fluoro-5-methylnitrobenzene (0.940 g, 4 mmol) was stirred with 25% methanolic NaOMe (1.00 mL) at 60° C. for overnight. The resulting solution was then filtered through a pad of Celite, washed with methanol and the methanolic solution was concentrated to give 3-aminosulfonyl-4-methoxy-5-methylnitrobenzene. LCMS: purity: 100%, MS (m/e): 247 (MH+).

Aufarbeitung

filtrationThe resulting solution was then filtered through a pad of Celite
washwashed with methanol
concentrationthe methanolic solution was concentrated

Quellen und Nachweise

ORD-Eintrag: ord-c6a1ba3c7b7445c780e7f8c8ffa20043
Quelldatensatz: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08399472B2

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