Iodoethane → 2-(1,3-Thiazol-4-yl)butanoic acid

HRID 1947752

Reaktionsgleichung

[S:1]1[CH:5]=[C:4]([CH2:6][C:7]([OH:9])=[O:8])[N:3]=[CH:2]1.[CH2:10](I)[CH3:11]>>[S:1]1[CH:5]=[C:4]([CH:6]([CH2:10][CH3:11])[C:7]([OH:9])=[O:8])[N:3]=[CH:2]1

Komponenten

Edukt 2

HCID 6340Iodoethane

HCID 2362624-Thiazoleacetic acid

Produkt 1

HCID 579076022-(1,3-Thiazol-4-yl)butanoic acid

Versuchsvorschrift

2-(1,3-Thiazol-4-yl)butanoic acid was prepared from commercially available 1,3-thiazol-4-ylacetic acid and ethyl iodide using a procedure analogous to that used to prepare Intermediate 26. 1H NMR (500 MHz, CDCl3) δ: 0.95 (t, J=7.3, 3H), 1.25 (t, J=7.3, 3H), 1.95-2.05 (m, 1H), 2.08-2.17 (m, 1H), 3.88 (t, J=7.6, 1H), 4.15-4.23 (m, 2H), 7.22 (d, J=1.8, 1H), 8.77 (d, J=1.8, 1H).

Quellen und Nachweise

ORD-Eintrag: ord-6e9f67b92b7747b09dc04d7ca64d4a90
Quelldatensatz: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08399480B2

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