Hydrochloric Acid → 2-(5-(4-methoxyphenyl)-2-oxopyridin-1(2H)-yl)acetic acid

HRID 1948208

Reaktionsgleichung

Reaktionsgleichung von HRID 1948208
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[CH:11][C:12](=[O:21])[N:13]([CH2:15][C:16]([O:18]CC)=[O:17])[CH:14]=2)=[CH:5][CH:4]=1.[OH-].[Li+].Cl>O.CCO>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:10]=[CH:11][C:12](=[O:21])[N:13]([CH2:15][C:16]([OH:18])=[O:17])[CH:14]=2)=[CH:7][CH:8]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 69344830ethyl 2-(5-(4-methoxyphenyl)-2-oxopyridin-1(2H)-yl)acetate

Produkt 1

HCID 694409442-(5-(4-methoxyphenyl)-2-oxopyridin-1(2H)-yl)acetic acidAusbeute 76 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 19096565Water ethanolLösungsmittel

Versuchsvorschrift

According to Scheme 9 Step 2: To a solution of ethyl 2-(5-(4-methoxyphenyl)-2-oxopyridin-1(2H)-yl)acetate (1 eq, 3.38 mmol, 0.97 g) in water/EtOH (1:1, 20 mL) at 0° C. was added lithium hydroxide (10 eq, 33.8 mmol, 1.44 g). The reaction was then allowed to warm to room temperature and stirred for 2 hours. The reaction was then cooled to 0° C. and acidified with HCl 1M solution till pH=2. The resulting precipitate was filtered under reduced pressure to yield 2-(5-(4-methoxyphenyl)-2-oxopyridin-1(2H)-yl)acetic acid (2.56 mmol, 0.66 g, 76%) as a white solid.

Aufarbeitung

  1. temperatureThe reaction was then cooled to 0° C.
  2. filtrationThe resulting precipitate was filtered under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-afc665fb4d5643edab2465762171a31d
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08399493B2

Verknüpfte Notizen

Wird geladen…