Cyclopropylamine → [6-(2-Chloro-imidazol-1-yl)-pyrimidin-4-yl]-cyclopropyl-amine

HRID 19500Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 19500
Cl[C:2]1[CH:7]=[C:6]([N:8]2[CH:12]=[CH:11][N:10]=[C:9]2[Cl:13])[N:5]=[CH:4][N:3]=1.[CH:14]1([NH2:17])[CH2:16][CH2:15]1>CO>[Cl:13][C:9]1[N:8]([C:6]2[N:5]=[CH:4][N:3]=[C:2]([NH:17][CH:14]3[CH2:16][CH2:15]3)[CH:7]=2)[CH:12]=[CH:11][N:10]=1

Komponenten

4

Edukt 2

HCID 69828CyclopropylamineHCID 589730674-Chloro-6-(2-chloro-imidazol-1-yl)-pyrimidine

Produkt 1

HCID 58973138[6-(2-Chloro-imidazol-1-yl)-pyrimidin-4-yl]-cyclopropyl-amineAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

4-Chloro-6-(2-chloro-imidazol-1-yl)-pyrimidine (0.85 g, 4 mmol) and cyclopropylamine (1.4 mL, 20 mmol) were mixed in 10 mL methanol and stirred at 50° C. for 12 hours. After reaction was complete, the solvent was removed by rotary evaporation. The crude product was washed with water and taken to dryness to give the title compound (0.84 g, 90%); 1H NMR 400 MHz (DMSO-d6) δ 8.45 (s, 1H), 8.17 (d, 1H), 7.75 (s, 1 H), 7.08 (s, 1H), 6.80 (d, 1H), 3.34 (s, 1H), 0.78 (br, 2H), 0.52 (br, 2H); MS m/z 236.4 (M+1).

Aufarbeitung

  1. customAfter reaction
  2. customthe solvent was removed by rotary evaporation
  3. washThe crude product was washed with water

Quellen und Nachweise

ORD-Eintrag
ord-7639acae788645ac9f0a1c2194593ae7
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07745437B2

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