1-Bromo-4-fluoro-2-nitrobenzene → HCID 23087411, Verbindung

HRID 1950052

Reaktionsgleichung

Reaktionsgleichung von HRID 1950052
Br[C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].C([Sn](CCCC)(CCCC)C1C=CC(F)=CC=1[N+]([O-])=O)CCC.FC(F)(F)S(O[C:41]1[CH2:50][CH2:49][C:48]2[C:43](=[CH:44][CH:45]=[C:46]([O:51][CH3:52])[CH:47]=2)[CH:42]=1)(=O)=O>>[F:8][C:5]1[CH:6]=[CH:7][C:2]([C:41]2[CH2:50][CH2:49][C:48]3[C:43]([CH:42]=2)=[CH:44][CH:45]=[C:46]([O:51][CH3:52])[CH:47]=3)=[C:3]([N+:9]([O-:11])=[O:10])[CH:4]=1

Komponenten

4

Edukt 3

HCID 27733831-Bromo-4-fluoro-2-nitrobenzeneHCID 153302566-Methoxy-3,4-dihydronaphthalen-2-yl trifluoromethanesulfonateHCID 23087155Tributyl(4-fluoro-2-nitrophenyl)tin

Produkt 1

HCID 23087411HCID 23087411, Verbindung

Versuchsvorschrift

Synthesized from 1-bromo-4-fluoro-2-nitrobenzene according to an analogous synthetic method to Preparation Example 76, tributyl(4-fluoro-2-nitrophenyl)tin (7.1 g) and 6-methoxy-3,4-dihydronaphthalen-2-yl trifluoromethanesulfonate (2.2 g) were used according to an analogous synthetic method to Preparation Example 77 to provide 3-(4-fluoro-2-nitrophenyl)-7-methoxy-1,2-dihydronaphthalene (1.4 g). The total amount of this compound was used according to an analogous synthetic method to Example 30 to provide the title compound (1.1 g).

Aufarbeitung

  1. customwere used according to an analogous synthetic method to Preparation Example 77

Quellen und Nachweise

ORD-Eintrag
ord-8fdfb94326544a2c9c87c60ee222323c
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08399520B2

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